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Target intelligence / Profile preview
Neurotrophic Tyrosine Receptor Kinase (NTRK)
- Target
- NTRK
- Molecular classification
- Receptor Tyrosine Kinase, RTK, Receptor
01
Overview
Neurotrophic tyrosine receptor kinases (NTRKs) are a family of genes encoding transmembrane receptor tyrosine kinases, which play essential roles in the development, function, and survival of neurons. The NTRK gene family consists of three members: NTRK1, NTRK2, and NTRK3. These genes encode the proteins TRKA, TRKB, and TRKC respectively. NTRK fusions can drive tumorigenesis by promoting uncontrolled cellular proliferation/survival via persistent activation of MAP kinase pathways. Selective inhibitors targeting these kinases represent important advances in precision oncology.
- Other names
- TrkATrkBTrkCNTRK1NTRK2NTRK3High affinity nerve growth factor receptorp140-TrkATrk-Atyrosine kinase receptor A
02
Mechanism of action
Tyrosine kinase inhibitor
03
Biological functions
Signal transductionCell survivalCell proliferationNeuronal differentiationSynaptic plasticityNervous system development
04
Disease associations
CancerCongenital insensitivity to pain with anhidrosis (CIPA)Intellectual disability
05
Biomarkers
NTRK gene fusions
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