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Neurotrophic Tyrosine Receptor Kinase 2
- Molecular classification
- Receptor, Tyrosine Kinase Receptor
01
Overview
Neurotrophic tyrosine receptor kinase 2 (NTRK2), also known as TrkB, is a membrane-bound receptor tyrosine kinase that plays a crucial role in the development and function of the nervous system. It is a high-affinity catalytic receptor for BDNF, NT-4, and NT-3, activating intracellular signaling cascades involved in neuronal survival, differentiation, and synaptic plasticity. NTRK2/TrkB dysregulation is implicated in neurological disorders and its gene fusions act as oncogenic drivers across diverse cancers.
- Other names
- TrkBTropomyosin Receptor Kinase B
02
Mechanism of action
Tyrosine kinase inhibition; Modulation of neurotrophin signaling
03
Biological functions
Neuronal survivalNeuronal differentiationSynaptic plasticitySignal transductionLearningMemoryRegulation of cell morphologyCalcium influx
04
Disease associations
CancerNeurological disorders
05
Safety considerations
Potential for off-target effects with kinase inhibitorsResistance development in cancer therapyNeurological side effects
06
Biomarkers
NTRK gene fusions
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