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Target intelligence / Profile preview
Neurotrophic Tyrosine Receptor Kinase 3 (NTRK3)
- Target
- NTRK3
- Molecular classification
- Receptor tyrosine kinase, Receptor
01
Overview
NTRK3 encodes the TrkC protein, a receptor tyrosine kinase that binds neurotrophin-3 (NT-3). Upon ligand binding, TrkC activates downstream signaling pathways involved in neuronal differentiation, survival, and synapse development. NTRK3 gene fusions are oncogenic drivers in various cancers and are actionable biomarkers for targeted therapy with TRK inhibitors.
- Other names
- TrkCTropomyosin receptor kinase C
02
Mechanism of action
TRK inhibition
03
Biological functions
Neuronal differentiationNeuronal survivalCell signalingSynapse developmentCell proliferationCell motility
04
Disease associations
Neurological disordersSensory neuropathiesNeurodegenerationCancer
05
Safety considerations
Potential for off-target effects of TRK inhibitorsResistance to TRK inhibitors
06
Interacting drugs
Larotrectinib
1 more in the full profile.
07
Biomarkers
NTRK gene fusionsTrkC expression level
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