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Target intelligence / Profile preview
Neurotrophic Tyrosine Receptor Kinase Type 1 (NTRK1)
- Target
- NTRK1
- Molecular classification
- Receptor tyrosine kinase, Receptor
01
Overview
NTRK1 encodes a receptor tyrosine kinase that binds nerve growth factor (NGF). Upon ligand binding, NTRK1 dimerizes and autophosphorylates, initiating downstream signaling cascades that promote neuronal differentiation, survival, and proliferation. Mutations or rearrangements in NTRK1 are associated with various cancers and neurological disorders, making it a target for cancer therapy.
- Other names
- TrkATropomyosin receptor kinase AHigh affinity nerve growth factor receptorTRKAp140-TrkATRK1-transforming tyrosine kinase protein
02
Mechanism of action
NTRK inhibitors bind to the ATP-binding pocket of the NTRK kinase domain, preventing autophosphorylation and downstream signaling.
03
Biological functions
Neuronal differentiationNeuronal survivalCell proliferationApoptosis avoidanceNociceptionSignal transduction
04
Disease associations
Congenital insensitivity to pain with anhidrosisCognitive disability/intellectual impairmentPapillary thyroid carcinomaFamilial medullary thyroid carcinomaCancer
05
Safety considerations
Resistance to NTRK inhibitors can emerge through mutations in the kinase domain.
06
Interacting drugs
NTRK inhibitors
07
Biomarkers
NTRK gene fusions
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