Target intelligence / Profile preview

Neurotrophic Tyrosine Receptor Kinase Type 2 (NTRK2)

Target: NTRK2
Molecular classification: Receptor Tyrosine Kinase

Overview

NTRK2 is a membrane-bound receptor tyrosine kinase that acts as a high-affinity catalytic receptor for neurotrophins such as BDNF, NT-4, and NT-3. Upon ligand binding, it activates downstream signaling pathways like Ras-MAPK, PI3K-Akt, and PLCγ, regulating neuronal differentiation, cell survival, axon/dendrite growth, and synaptic plasticity. Dysregulation of NTRK2 is associated with obesity, mood disorders, and potential roles in cancer.

Other names: TrkBNeurotrophic receptor tyrosine kinase 2

Mechanism of action

N/A

Biological functions

Neuronal differentiationCell survivalAxon/dendrite growthSynaptic plasticityAstrocyte morphogenesisSignal transduction

Disease associations

ObesityMood disordersCancer

Beyond the preview

Go deeper on Neurotrophic Tyrosine Receptor Kinase Type 2 (NTRK2).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Neurotrophic Tyrosine Receptor Kinase Type 2 (NTRK2).

Explore the full profile