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Target intelligence / Profile preview
Neurotrophic Tyrosine Receptor Kinase Type 3 (NTRK3)
- Target
- NTRK3
- Molecular classification
- Receptor Tyrosine Kinase, Transmembrane receptor
01
Overview
NTRK3 encodes the TrkC receptor tyrosine kinase, which is activated by NT-3 and plays a crucial role in nervous system development, function, and also plays a role in heart development. NTRK3 fusions are oncogenic drivers across diverse cancers and are targetable with selective TRK inhibitors. Aberrant TrkC activity has been implicated in neurodegenerative diseases.
- Other names
- TrkCTropomyosin receptor kinase C
02
Mechanism of action
Selective TRK inhibitors; inhibit tyrosine kinase activity of TRK receptors, blocking downstream signaling.
03
Biological functions
Signal transductionCell survivalCell proliferationCell motilityNeuronal differentiationSynaptogenesisAdhesion
04
Disease associations
Neurological DisordersNeurodegenerative diseaseCancer
05
Safety considerations
Potential for off-target effects due to kinase inhibitor activity.Resistance development to TRK inhibitors.
06
Interacting drugs
Larotrectinib
1 more in the full profile.
07
Biomarkers
NTRK gene fusions
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