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Target intelligence / Profile preview
Neurotrophin-3 (NT-3)
- Target
- NT-3
- Molecular classification
- Neurotrophin, Growth Factor
01
Overview
Neurotrophin-3 (NT-3) is a protein growth factor and neurotrophic factor that plays a critical role in the development, maintenance, and function of the nervous system. It belongs to the nerve growth factor (NGF) family of neurotrophins and is essential for neuronal survival, differentiation, and synaptic plasticity. NT-3 primarily binds with high affinity to tropomyosin receptor kinase C (TrkC), a receptor tyrosine kinase. It can also activate TrkB but with lower affinity. Additionally, it interacts with p75NTR—a low-affinity pan-neurotrophin receptor. NT-3 has been shown to promote angiogenesis. Therapeutically, it is explored for promoting nerve regeneration after injury and investigated for ischemic disease due to proangiogenic effects. It is also targeted by small-molecule inhibitors/modulators aimed at TRK family kinases due to their involvement in cancer when aberrantly activated/fused (NTRK fusions).
- Other names
- NTF3
02
Mechanism of action
Small-molecule inhibitors/modulators aimed at TRK family kinases
03
Biological functions
Neuronal survivalNeuronal differentiationSynaptic plasticityNeurogenesisAngiogenesis
04
Disease associations
Sensory neuron deficitsNerve injuryIschemic diseaseCancer (NTRK fusions)
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