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Target intelligence / Profile preview
Neurotrophin-4 (NTF4)
- Target
- NTF4
- Molecular classification
- Growth factor, Neurotrophin family, Secreted protein
01
Overview
Neurotrophin-4 (NTF4) is a member of the neurotrophin family of growth factors responsible for the survival, development, and function of neurons in the central and peripheral nervous systems[1][2][8]. Unlike other neurotrophins, NTF4-deficient mice only show minor cellular changes and generally develop normally[1]. NTF4 signals mainly through the TrkB tyrosine kinase receptor, driving neuronal survival and differentiation, and may also promote ameloblast differentiation[2][3][8]. Pathological variants in the NTF4 gene are associated with certain types of glaucoma[1][6]. There are no currently approved drugs that specifically target NTF4, but modulation of its downstream pathways (especially via TrkB) remains a research interest for neuroprotection and neurodegenerative disease[2].
- Other names
- Neurotrophin-4NTF4NTF5NT-4NT-5NT-4/5GLC1ONeurotrophin-5Neutrophic factor 4neurotrophic factor 4GLC10NT4NT5neurotrophin-4neurotrophic factor 5neurotrophin 5neutrophic factor 4
02
Mechanism of action
Promotion of neuronal survival via binding and activating TrkB receptor tyrosine kinase
03
Biological functions
Neuronal survivalNeuronal differentiationRegulation of apoptosisPromotion of ameloblast differentiation
04
Disease associations
Glaucoma (open angle and juvenile forms)Potential role in neurodegenerative disease
05
Safety considerations
No notable safety or therapeutic liabilities directly for Neurotrophin-4 modulation described; general concerns for neurotrophin pathway modulation include uncontrolled cell growth or unwanted neuronal survival
06
Interacting drugs
No direct drugs targeting Neurotrophin-4 are currently approved; neurotrophin signaling modulators or TrkB agonists/antagonists may interact indirectly
07
Biomarkers
Candidate biomarker in glaucoma (see genetic association)Possible biomarker for neurotrophic support deficits
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