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The neurotrophin 4 pseudogene (ENSG00000268669) is a nonfunctional genomic sequence similar to the neurotrophin 4 gene. Pseudogenes typically arise by gene duplication or retrotransposition and harbor features like a high sequence similarity to their parent gene but an inability to produce a functional protein product due to disabling mutations such as frameshifts and premature stop codons[1][2][5]. While some pseudogenes may contribute to gene regulation through RNA-mediated mechanisms, most are not biologically active and are not considered therapeutic targets. The neurotrophin 4 pseudogene is localized on human chromosome 19 near the functional NTF4 gene, likely due to a recent gene duplication event[2].
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