Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Neurturin (NRTN)
- Target
- NRTN
- Molecular classification
- Growth Factor, GDNF Family Ligand, Neurotrophic Factor, TGF-β superfamily member
01
Overview
Neurturin is a protein growth factor belonging to the GDNF family, crucial for the survival, development, and maintenance of various neuron types. It signals through the GFRα2 receptor and RET tyrosine kinase, playing roles in both neuronal and non-neuronal tissues. It is implicated in cancer, neuropathic pain, and neuronal plasticity.
- Other names
- NTNprepro-neurturinNTNRalphaGDNFR-bRet ligand 2RETL2TGF-beta-related neurotrophic factor receptor 2TrnR2GFRα2
02
Mechanism of action
Binds to GFRα2 receptor, recruits RET tyrosine kinase, leading to downstream signaling via MAP kinase pathway.
03
Biological functions
Neuronal survivalNeuronal developmentNeuronal maintenanceSignal transductionRegulation of nervous system development
04
Disease associations
CancerNeuropathic painNeurodegenerative diseases
Beyond the preview
Go deeper on Neurturin (NRTN).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Neurturin (NRTN).