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Target intelligence / Profile preview
Neutral alpha-glucosidase C (GANC)
- Target
- GANC
- Molecular classification
- Enzyme, Glycosyl hydrolase family, Glycosidase
01
Overview
Neutral alpha-glucosidase C is a human enzyme encoded by the GANC gene. It is a member of the glycosyl hydrolase family and catalyzes the hydrolysis of terminal, non-reducing alpha-linked glucose residues from carbohydrates. This enzyme plays a role in carbohydrate metabolism, particularly in processing oligosaccharides and polysaccharides into glucose. Unlike the more clinically targeted lysosomal/acid alpha-glucosidase (GAA), neutral alpha-glucosidase C is not a major target for current drugs but may be relevant in research as a biomarker in some clinical scenarios, such as reproductive health[1][5][6].
- Other names
- glucosidase alpha, neutral CGANC
02
Mechanism of action
not a classic therapeutic target; by analogy, inhibition would block terminal glucose cleavage in carbohydrates[2]
03
Biological functions
Carbohydrate metabolismCatalysis of glycosidic bond hydrolysisCatalytic activity on alpha-linked glucose residues
04
Disease associations
Other (no strong disease linkage widely established, but enzyme activity used as a marker in reproductive disorders[6])
05
Safety considerations
no documented safety concerns regarding as a drug targetno clinical-stage neutral alpha-glucosidase C inhibitors
06
Biomarkers
Levels may be used as a biomarker to distinguish certain types of azoospermia[6]
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