Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Neutral Sphingomyelinase 2 (nSMase2)
- Target
- nSMase2
- Molecular classification
- Enzyme, Hydrolase
01
Overview
Neutral sphingomyelinase 2 (nSMase2) is a membrane-bound enzyme that catalyzes the hydrolysis of sphingomyelin to generate ceramide and phosphocholine. Ceramide, a bioactive lipid, is involved in various cellular processes including inflammatory signaling, exosome generation, cell growth regulation, and apoptosis. nSMase2 is implicated in diseases such as cancer, neurodegeneration, and inflammatory disorders, making it a potential therapeutic target.
- Other names
- SMPD3
02
Mechanism of action
Lipid competitive inhibitor (e.g., GW4869)
03
Biological functions
Ceramide productionInflammatory signalingExosome generationCell growth regulationApoptosis inductionImmune responseBone mineralizationHIV maturation
04
Disease associations
CancerNeurodegenerative diseaseInflammationVascular dysfunctionHIV/AIDS
05
Interacting drugs
GW4869
Beyond the preview
Go deeper on Neutral Sphingomyelinase 2 (nSMase2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Neutral Sphingomyelinase 2 (nSMase2).