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Target intelligence / Profile preview
Neutrophil (PMN)
- Target
- PMN
- Molecular classification
- White blood cell, Granulocyte, Leukocyte
01
Overview
Neutrophils are the most abundant type of white blood cell, playing a crucial role in the innate immune system. They defend against invading pathogens through phagocytosis, degranulation, and NETosis. Their numbers and function are clinically relevant in various conditions, including infections, inflammation, and immunodeficiencies.
- Other names
- Polymorphonuclear leukocyteNeutrophilic granulocyteNeutrophil granulocyte
02
Mechanism of action
N/A
03
Biological functions
PhagocytosisDegranulationNETosisChemotaxisInnate immunityInflammation modulationAntimicrobial defense
04
Disease associations
InfectionInflammationImmunodeficiencyBone marrow disorders
05
Safety considerations
Neutropenia (increased risk of infection)Excessive inflammationAutoimmune diseases (involving neutrophil dysfunction)Sepsis
06
Interacting drugs
Chemotherapy agents (leading to neutropenia)
2 more in the full profile.
07
Biomarkers
Neutrophil countNeutrophil activation markersMarkers of NETosis
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