Neutrophil cell membrane proteins

Neutrophil cell membrane proteins encompass a broad array of surface-expressed molecules that dictate the functional lifecycle of neutrophils, the most prevalent type of white blood cell in the human immune system (PubMed, 2021). This group includes essential receptors such as chemokine receptors (CXCR1, CXCR2), adhesion molecules (integrins like Mac-1 and selectins like L-selectin), and Fc receptors (CD16, CD32, CD64), which collectively enable neutrophils to sense inflammatory signals, adhere to vascular endothelium, and migrate into tissues (NIH, 2023). In pathological states, dysregulated neutrophil activation and recruitment contribute to chronic inflammation, tissue damage, and tumor progression (Nature Reviews Immunology, 2022). While not a single therapeutic target, individual proteins within this group, such as CXCR1/2 and Mac-1 (CD11b/CD18), are major focuses for drug development to treat inflammatory and autoimmune disorders (ClinicalTrials.gov, 2023). Additionally, the entire membrane proteome is increasingly utilized in biomimetic nanotechnology, where neutrophil membranes are used to coat nanoparticles to improve drug delivery and target inflammation sites (ACS Nano, 2020).

Other names

Neutrophil surface proteinsNeutrophil membrane proteomeNeutrophil membrane receptors

Chemokine receptor antagonism, integrin blockade, and adhesion molecule inhibition to modulate neutrophil recruitment and activation.