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Neutrophil Chemotaxis
- Molecular classification
- Cellular process, Signaling pathway
01
Overview
Neutrophil chemotaxis refers to the directed movement of neutrophils toward sites of tissue damage or infection in response to external chemical stimuli. This process is a fundamental component of the innate immune response and enables rapid recruitment of neutrophils to inflamed tissues. It is orchestrated by chemoattractants such as fMLF peptides, C5a complement fragment, and IL‑8/CXCL8, acting on GPCRs like FPR family, CXCR1/CXCR2, and C5aR, triggering intracellular pathways involving Rho GTPases and PI(3,4,5)P3-mediated actin polymerization.
- Other names
- Neutrophil MigrationNeutrophil TraffickingChemotactic gradient-guided neutrophil movement
02
Biological functions
Immune responseDirected cell migrationInflammationHost defensePhagocytosis
03
Disease associations
InfectionInflammationChronic inflammatory diseasesAutoimmune diseasesImmunodeficiency
04
Safety considerations
Excessive neutrophil recruitment leading to tissue damageImpaired neutrophil chemotaxis leading to increased susceptibility to infections
05
Biomarkers
P2RX1 expression
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