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Neutrophil collagenase (MMP-8)
- Target
- MMP-8
- Molecular classification
- Enzyme, Matrix metalloproteinase (MMP), Peptidase family M10, Metalloendopeptidase
01
Overview
Neutrophil collagenase/MMP‑8 is an essential enzyme involved both in normal connective tissue turnover and various disease states characterized by excessive matrix degradation or inflammation.
- Other names
- Matrix metalloproteinase-8PMNL collagenaseMNL-CL
02
Mechanism of action
Inhibition of MMP-8 activity
03
Biological functions
Extracellular matrix breakdownTissue remodelingCollagen degradation
04
Disease associations
ArthritisPeriodontitisCancer metastasisVascular diseaseInflammationAtheroma
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