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Target intelligence / Profile preview
Neutrophil cytosolic factor 1 (p47-phox)
- Target
- p47-phox
- Molecular classification
- Enzyme subunit
01
Overview
Neutrophil cytosolic factor 1 (NCF1), also known as p47-phox, is a crucial cytosolic subunit of the NADPH oxidase (NOX) enzyme complex. NOX is essential for generating reactive oxygen species (ROS) in phagocytes, which are used to kill engulfed pathogens. NCF1 is activated by phosphorylation, leading to its translocation to the membrane and assembly with other NOX components to produce superoxide. NCF1 dysfunction is strongly associated with chronic granulomatous disease and increased risk for autoimmune disorders.
- Other names
- NCF1_HUMANp47phoxSH3PXD1A
02
Mechanism of action
Not applicable (target is a protein subunit, not directly druggable itself, but involved in a druggable pathway)
03
Biological functions
Immune responseROS productionPhagocytosis
04
Disease associations
Chronic Granulomatous DiseaseAutoimmune DiseasesInflammation
05
Safety considerations
Modulation of NOX activity needs careful control to balance pathogen clearance and tissue damage.Aberrant ROS production can contribute to inflammatory diseases and vascular dysfunction.
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