Neutrophil cytosolic factor 1C (NCF1C)

Neutrophil cytosolic factor 1C (NCF1C) is a pseudogene highly similar in sequence to the functional neutrophil cytosolic factor 1 (NCF1) gene, which encodes the 47 kDa cytosolic subunit (p47phox) of the phagocyte NADPH oxidase complex. The NCF1C pseudogene, found near NCF1 on chromosome 7q11.23, carries a frameshift mutation (dinucleotide delta-GT deletion in exon 2) that results in a truncated, nonfunctional open reading frame, and it is not believed to produce a protein. NCF1C is not a protein-coding gene and plays no direct biological or therapeutic role; however, recombination events between NCF1 and its related pseudogenes (such as NCF1C) can lead to inactivation of NCF1, contributing to chronic granulomatous disease. NCF1C is not itself a therapeutic target, and there are no known drugs, disease roles, or direct biological functions associated with it[2][3].

Other names

Putative neutrophil cytosol factor 1CSH3PXD1CNCF-1CPutative SH3 and PX domain-containing protein 1C