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Target intelligence / Profile preview
Neutrophil Elastase (NE)
- Target
- NE
- Molecular classification
- Enzyme, Serine Protease
01
Overview
Neutrophil elastase (NE) is a serine protease enzyme primarily found in the azurophilic granules of neutrophils. It plays a crucial role in host defense by degrading engulfed microorganisms and organic molecules, as well as modulating inflammation and tissue remodeling. Aberrant expression or regulation contributes significantly to several diseases, including chronic lung diseases and pulmonary arterial hypertension. Consequently, it is an important drug discovery target for inhibitor development aimed at reducing pathological proteolysis without compromising host defense functions.
- Other names
- Leukocyte elastaseSerine elastaseHuman leukocyte elastase (HLE)Granulocyte elastasePolymorphonuclear leukocytes (PMNs) elastaseELANEELA2
02
Mechanism of action
Inhibition of neutrophil elastase activity, preventing degradation of extracellular matrix proteins and modulation of inflammatory responses.
03
Biological functions
Immune responseExtracellular matrix degradationInflammationTissue remodelingCytokine modulationChemokine regulation
04
Disease associations
Chronic lung diseases (Emphysema, Cystic Fibrosis, COPD)Pulmonary arterial hypertensionCyclic NeutropeniaSevere Congenital NeutropeniaInflammation
05
Safety considerations
Potential for impaired host defense due to inhibition of neutrophil functionOff-target effects of inhibitorsRisk of bleeding complications
06
Interacting drugs
α1-antitrypsin
1 more in the full profile.
07
Biomarkers
Neutrophil elastase levels in bronchoalveolar lavage fluidNeutrophil elastase levels in serum/plasmaELANE mutations
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