Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Neutrophil Extracellular Trap (NET)
- Target
- NET
- Molecular classification
- Extracellular Matrix, Complex, DNA-based structure
01
Overview
Neutrophil extracellular traps (NETs) are web-like structures released by neutrophils, a type of white blood cell, as part of the innate immune response. These structures are primarily composed of decondensed chromatin (DNA) decorated with histones and various antimicrobial proteins derived from neutrophil granules. The main function of NETs is to trap and neutralize invading pathogens.
02
Mechanism of action
NETs trap and neutralize invading pathogens by immobilizing them in the extracellular space and exposing them to high local concentrations of antimicrobial agents.
03
Biological functions
Immune responsePathogen entrapmentAntimicrobial activityInflammation modulation
04
Disease associations
Autoimmune diseasesChronic inflammatory diseasesThrombosis/coagulation disordersAtherosclerosisVasculitisWound healing complicationsCancer
05
Safety considerations
Excessive NET formationAutoantigen formationDamage-associated molecular pattern (DAMP) releaseThrombosis promotion
06
Biomarkers
DNA-histone complexesMyeloperoxidase-DNA complexesElastase-DNA complexes
Beyond the preview
Go deeper on Neutrophil Extracellular Trap (NET).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Neutrophil Extracellular Trap (NET).