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Target intelligence / Profile preview
Neutrophil Extracellular Trap Formation (NETosis)
- Target
- NETosis
- Molecular classification
- Other
01
Overview
Neutrophil extracellular trap (NET) formation is a unique antimicrobial defense mechanism employed by neutrophils. NETs are web-like structures composed primarily of decondensed chromatin (DNA and histones) decorated with various antimicrobial proteins. These structures are released into the extracellular space to immobilize, entrap, and kill invading pathogens. While beneficial for pathogen control, excessive or dysregulated NET formation has been implicated in various diseases, including autoimmune diseases, thrombosis, and cancer. It can occur via suicidal or vital NETosis. Detection and standardization of assays remain an area needing consensus development.
- Other names
- NETsNET releaseExtracellular traps
02
Mechanism of action
N/A
03
Biological functions
Innate immunityAntimicrobial defenseExtracellular matrix remodelingInflammationCell death
04
Disease associations
Autoimmune diseasesSystemic lupus erythematosusRheumatoid arthritisCystic fibrosisPsoriasisThrombosis/coagulation disordersDiabetes complicationsAtherosclerosis/vasculitisWound healing defectsPeriodontitisCancerSterile inflammation
05
Safety considerations
Excessive NET formationAutoimmunityThrombosisTissue damageInflammationPromotion of metastasis
06
Interacting drugs
Phorbol myristate acetate (PMA)
2 more in the full profile.
07
Biomarkers
DNAHistonesMyeloperoxidase (MPO)Neutrophil elastaseCathepsin GLactoferrinGelatinase
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