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Target intelligence / Profile preview
New York Esophageal Squamous Cell Carcinoma 1 (NY-ESO-1)
- Target
- NY-ESO-1
- Molecular classification
- Cancer/testis antigen, Protein
01
Overview
New York esophageal squamous cell carcinoma 1 (NY-ESO-1) is a well-characterized cancer/testis antigen (CTA) notable for its exceptional immunogenicity and restricted expression pattern. It is encoded by the CTAG1B gene and produces a protein consisting of 180 amino acids. It exhibits highly restricted normal tissue expression, being found primarily in adult testis, while being aberrantly re-expressed in various malignancies. This re-expression makes NY-ESO-1 an attractive target for tumor-specific immunotherapy. Positive expression of NY‑ESO‑1 in solid tumors has been associated with increased mortality.
- Other names
- CTA 1BCTAG1B
02
Mechanism of action
NY-ESO-1 targeting therapies stimulate endogenous anti-tumor immunity or directly provide effector cells capable of recognizing tumor-expressed NY-ESO-1.
03
Biological functions
Immune responseCell cycle regulationCell growth
04
Disease associations
Esophageal squamous cell carcinomaMelanomaNon-small cell lung cancerColorectal cancerCancer
05
Safety considerations
Potential for off-target effects of immunotherapyRisk of autoimmunity
06
Biomarkers
NY-ESO-1 antibody levelsNY-ESO-1-specific T lymphocytesNY-ESO-1 expression in tumor tissue
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