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Target intelligence / Profile preview
New York Esophageal Squamous Cell Carcinoma Antigen 1 (NY-ESO-1)
- Target
- NY-ESO-1
- Molecular classification
- Cancer/Testis Antigen, Tumor-associated antigen
01
Overview
NY-ESO-1, also known as Cancer/Testis Antigen 1B (CTAG1B), is a highly immunogenic tumor-associated antigen that belongs to the cancer/testis antigen (CTA) family. It is normally expressed only in embryonic testis and not in adult somatic tissues, but aberrantly re-expressed in various cancers, making it a target for cancer immunotherapy.
- Other names
- Cancer/Testis Antigen 1BCTAG1BCTAG-1
02
Mechanism of action
Target of cancer vaccines and adoptive T-cell therapies; elicits anti-tumor immune response
03
Biological functions
Cell cycle progressionGrowth regulationApoptosis (potential)Self-renewal/differentiation (potential)Immune response
04
Disease associations
Cancer
05
Safety considerations
On-target, off-tumor toxicity (potential expression in normal tissues)Immune-related adverse events
06
Biomarkers
NY-ESO-1 expression level in tumor tissueAntibody titers against NY-ESO-1T-cell response to NY-ESO-1 peptides
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