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Target intelligence / Profile preview
Newcastle Disease Virus (NDV)
- Target
- NDV
- Molecular classification
- Virus, Paramyxoviridae, RNA virus
01
Overview
Newcastle Disease Virus (NDV) is a highly contagious avian virus that causes Newcastle disease. It belongs to the family Paramyxoviridae. Different strains vary in virulence, affecting respiratory, nervous, digestive, and reproductive systems of birds. Some lentogenic/mesogenic strains are explored as vectors for oncolytic virotherapy.
- Other names
- Avian paramyxovirus type 1APMV-1Orthoavulavirus javaense
02
Mechanism of action
Varies depending on the strain; some strains are being explored for oncolytic virotherapy, selectively killing tumor cells.
03
Biological functions
Viral replicationHost cell entryImmune evasionDisease induction
04
Disease associations
Newcastle DiseaseAvian diseasePoultry disease
05
Safety considerations
High contagiousnessPotential for zoonotic transmission (mild conjunctivitis)Evolution of more virulent strainsSafety considerations for oncolytic virotherapy in humans
06
Interacting drugs
Interferon
3 more in the full profile.
07
Biomarkers
Viral loadAntibody titersF and HN protein expressionCytokine levels
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