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Nexilin F-actin binding protein (NEXN)
- Target
- NEXN
- Molecular classification
- Other (F-actin-binding, Z-disc-associated cytoskeletal protein)
01
Overview
Nexilin F-actin binding protein (NEXN) is a cytoskeletal protein that binds filamentous actin and is essential for maintaining the structural integrity of Z-discs in cardiomyocytes and skeletal muscle. It is crucial for mechanical stability during muscle contraction and tissue remodeling, particularly in the heart and vascular smooth muscle. NEXN mutations impair myofibrillar structure, leading to dilated and hypertrophic cardiomyopathies, and may be implicated in vascular remodeling processes. No direct drugs target NEXN, but pathogenic variants serve as important genetic biomarkers for inherited cardiomyopathies
- Other names
- CMH20NELINCDM2MF-actin-binding proteinNexilinNelinHypertrophic cardiomyopathy 20 protein
02
Biological functions
Maintenance of myofibrillar/Z-disc structural integrityRegulation of cell adhesionRegulation of cell migrationMaintenance of contractile phenotype in vascular smooth muscle cells
03
Disease associations
Cardiovascular diseaseDilated cardiomyopathyHypertrophic cardiomyopathyVascular disease/atherosclerosis
04
Safety considerations
Potential risk of cardiac dysfunction or cardiomyopathy from loss of function or pathogenic mutations
05
Biomarkers
Mutations are genetic markers for familial hypertrophic cardiomyopathy and dilated cardiomyopathy
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