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Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells Signaling Pathway (NF-κB signaling pathway)
- Target
- NF-κB signaling pathway
- Molecular classification
- Intracellular signal transduction pathway, Transcriptional regulatory pathway
01
Overview
The nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway is a central regulator of immune and inflammatory responses, cell survival, proliferation, and apoptosis. NF-κB refers to a family of transcription factors that are ubiquitously expressed in animal cells and play critical roles in the regulation of genes involved in immunity, inflammation, cell growth, and survival.
- Other names
- NF‑kΒ signaling pathwayNF-kB pathway
02
Mechanism of action
Targeting components within this pathway is an area under investigation for treating cancer (by modulating senescence/apoptosis), autoimmune conditions/inflammatory diseases/cardiovascular pathologies. Both inhibition and selective modulation strategies are being explored due to its dual roles depending on cellular context.
03
Biological functions
Immune responseInflammationCell survivalApoptosisGene expressionCell proliferationCell differentiation
04
Disease associations
CancerChronic inflammationAutoimmune diseasesCardiovascular diseasesSepsisNeuroplasticity disordersMemory processes
05
Safety considerations
Dysregulation or persistent activation/inhibition can contribute to chronic inflammation, autoimmune diseases, and cancer development/progression.Potential for both tumor-promoting and tumor-suppressing effects depending on context.
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