NF-kappa-B inhibitor zeta (IκBζ)

NF-kappa-B inhibitor zeta (IκBζ) is a nuclear regulatory protein encoded by the NFKBIZ gene. It is an atypical member of the IkappaB protein family, characterized by its ankyrin-repeat domains and distinct nuclear localization. IκBζ is induced by inflammatory stimuli such as interleukin-1 and lipopolysaccharide, and regulates the activity of NF-κB transcription factor complexes by directly interacting with p50 and p65 subunits. It can act both as an inhibitor and activator of NF-κB-dependent gene expression. IκBζ is essential for the transcriptional regulation of several cytokines, participates in chromatin remodeling, and its dysregulation is implicated in a range of diseases including autoimmune conditions, cancer (especially certain lymphomas), and psoriasis. The protein exists in several isoforms generated by alternative splicing, with IκBζ(L) being the major physiologically active form[1][3][4][5].

Other names

NFKBIZIKBZINAPMAILmolecule possessing ankyrin repeats induced by lipopolysaccharideIL-1 inducible nuclear ankyrin-repeat proteinnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor zetaNF-kappa-B inhibitor zeta

Modulation of NF-kappa B signaling via transcriptional regulation, Inhibition or activation of NF-κB-dependent gene expression through interaction with p50 homodimers and heterodimers, Chromatin remodeling at target gene promoters