NF-kappa-B-repressing factor (NKRF)

NF-kappa-B-repressing factor (NKRF) is a transcription factor encoded by the NKRF gene in humans. It mediates transcriptional repression of certain NF-κB-responsive genes by interacting with specific negative regulatory elements (NREs)[1]. NKRF localizes predominantly to the nucleolus, with a smaller pool found in the nucleoplasm and cytoplasm[1][3][4]. In addition to its classical role as a transcriptional repressor, NKRF interacts with the 5′–3′ exoribonuclease XRN2, forming a complex required for proper ribosomal RNA precursor processing and ribosome biogenesis[3][4]. NKRF also acts as a nucleolar heat shock protein (HSP), regulating nucleolar homeostasis and cell survival during proteotoxic stress[4]. Disruption of NKRF function may impact NF-κB signaling, ribosome assembly, and cellular responses to stress, linking it to fundamental processes in inflammation, stress response, and potentially disease states such as cancer and inflammatory disorders[2][4].

Other names

NKRFITBA4NRFNFKB repressing factor

Transcriptional repression of specific target genes by binding to negative regulatory elements, functional interaction with exoribonuclease XRN2 to regulate rRNA processing