NGG1 interacting factor 3 like 1 (NIF3L1)

NGG1 interacting factor 3 like 1 (NIF3L1) is a highly conserved human protein thought to function as a transcriptional corepressor, primarily through interaction with COPS2, which may contribute to the negative regulation of neuronal differentiation genes. It is widely expressed and has evidence for protein-protein interactions (including self-interaction and binding to specific co-regulators). Although originally mapped to a region associated with juvenile-onset amyotrophic lateral sclerosis, there is currently no proof that NIF3L1 is itself causative for this or any other human disease. No drugs target the protein, and it is not considered a classical drug target in current clinical or pharmaceutical practice.

Other names

NIF3-like protein 1ALS2CR1MDS015CALS-7Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 1 proteinGTP cyclohydrolase INIF3 (Ngg1 interacting factor 3, S.pombe homolog)-like 1NIF3 NGG1 interacting factor 3-like 1Putative GTP cyclohydrolase 1 type 2 NIF3L1NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)NIF3 NGG1 interacting factor 3-like 1 (S. pombe)

Not applicable; no drugs target this molecule directly