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Pseudogenes are DNA sequences that resemble functional genes but have undergone mutations which render them incapable of producing a functional protein product. Although they typically do not encode proteins, some pseudogenes can regulate their parental genes through transcription of non-coding RNAs such as lncRNAs, miRNAs, or siRNAs, impacting gene expression and epigenetic processes. However, only a minority of human pseudogenes (~20%) are transcriptionally active and contribute to the regulation of physiological or pathological functions, most commonly observed in cancer biology. The designation “NGRN pseudogene 3” does not correspond to any specific, therapeutically relevant target or known gene, and cannot be matched in major nomenclature resources, indicating a likely error or lack of recognition in biomedical literature.
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