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Target intelligence / Profile preview
NH3-dependent NAD synthetase (NadE)
- Target
- NadE
- Molecular classification
- Enzyme, Ligase, Carbon-nitrogen ligase
01
Overview
- Other names
- NAD synthetaseNAD+ synthetaseNicotinamide adenine dinucleotide synthetaseDeamido-NAD+ amidotransferaseAmmonia-dependent NAD+ synthetaseOutBGSP38
02
Mechanism of action
Inhibition of the final step of NAD+ biosynthesis by blocking the ATP-dependent amidation of nicotinic acid adenine dinucleotide (NaAD+), leading to NAD+ depletion and bacterial cell death [3.3.1, 3.3.5].
03
Biological functions
NAD+ biosynthesisATP-dependent amidationCofactor metabolic processBacterial spore germination
04
Disease associations
InfectionTuberculosisAnthraxBacterial pneumoniaGastritis (H. pylori)
05
Safety considerations
Selectivity over human NH3-dependent NAD synthetase (NADSYN2)Potential for cross-reactivity with human glutamine-dependent NAD synthetase (NADSYN1)Impact on host NAD+ homeostasis
06
Interacting drugs
Urea-sulfonamides (e.g., Compound 5838 analogs)
5 more in the full profile.
07
Biomarkers
Intracellular NAD+ levelsNaAD+ accumulationBacterial load/CFU countSpore germination rate (OD600)
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