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NHL repeat-containing protein 3 (NHLRC3)

Target: NHLRC3
Molecular classification: Other (NHL-repeat containing protein), Ubiquitin-protein ligase (predicted)

Overview

NHL repeat-containing protein 3 (NHLRC3) is a protein encoded by the NHLRC3 gene, and contains distinctive NCL-1, HT2A, and Lin-41 (NHL) protein family repeats[1][2][3][7]. NHL-repeat containing proteins in mammals are predicted to function primarily in enzymatic processes, in particular protein modification such as ubiquitination, through their putative ubiquitin-protein ligase activity[4][5][6]. NHLRC3 is listed as a protein-coding gene and displays alternative splicing, but there is currently no experimental evidence for a direct role in human disease, nor is it considered a validated therapeutic target[2][7]. Its functional associations include predicted involvement in the innate immune system and protein catabolism, but specific biological or clinical applications remain undefined[2][5].

Other names: NHL repeat containing 3NHLRC3

Biological functions

Protein modification via ubiquitination (predicted)Protein catabolic process (predicted)Possible involvement in innate immune system (suggested by pathway association)

Disease associations

Other (no validated direct disease associations; involved in molecular/cellular pathways, and appears in various cancer mutation/expression datasets but lacks defined causal disease role)

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