NHP2-like protein 1 (SNU13)

NHP2-like protein 1 (SNU13) is a highly conserved nuclear protein and core component of the [U4/U6.U5] tri-snRNP and box C/D small nucleolar ribonucleoprotein (snoRNP) complexes[1][2][3]. It specifically recognizes and binds a conserved RNA kink-turn motif found in the 5′ stem-loop of U4 small nuclear RNA (snRNA) and box C/D snoRNAs[1][2]. SNU13 acts as a molecular bridge, providing a platform for the association of other core sn/snoRNP proteins including NOP56, NOP58, and fibrillarin, and is critical for assembly of mature snRNPs and snoRNPs[1][2][3]. These complexes are essential for pre-mRNA splicing (especially in spliceosome function) and for site-specific modifications of ribosomal RNA during ribosome biogenesis[1][2][3]. SNU13 interacts with multiple assembly factors and chaperones (like NUFIP1, TIP48, TIP49), which help ensure correct complex formation and stability[1][4]. Structural studies have revealed that SNU13 is well-folded, with conformational flexibility important for precise RNA recognition and nucleation of ribonucleoprotein assemblies[1][2][3]. There are no direct reports of SNU13 being directly implicated as a therapeutic drug target or as a biomarker in human disease.

Other names

NHP2-like protein 1NHP2L1hSNU13FA-1SPAG12SNRNP15-515.5KHigh mobility group-like nuclear protein 2 homolog 1OTK27SNU13 homologU4/U6.U5 small nuclear ribonucleoprotein SNU13U4/U6.U5 tri-snRNP 15.5 kDa proteinsmall nuclear ribonucleoprotein 15.5kDa (U4/U6.U5)FA1NHPXSSFA1sperm specific antigen 1non-histone chromosome protein 2-like 1