NHP2 ribonucleoprotein pseudogene 1 (NHP2P1)

NHP2 ribonucleoprotein pseudogene 1 (NHP2P1) is a pseudogene—a non-functional genomic DNA sequence similar to the functional NHP2 ribonucleoprotein gene. Pseudogenes like NHP2P1 do not produce functional proteins and typically arise by duplication or retrotransposition events followed by accumulating disabling mutations such as stop codons or frameshifts, preventing proper expression and activity[2][4]. The functional NHP2 gene is involved in ribosome biogenesis and telomerase complex function, but NHP2P1 does not perform these roles nor is it implicated in disease or drug interactions[5]. Pseudogene status means NHP2P1 cannot serve as a drug target, biomarker, or play a direct role in biological function or disease. The abbreviation NHP2P1 distinguishes it from the functional NHP2 gene. NHP2P1 is not a receptor, enzyme, transporter, or related therapeutic target class. If your query intended to refer to the functional NHP2 ribonucleoprotein: that protein plays an essential role in H/ACA snoRNPs, ribosome biogenesis, rRNA pseudouridylation, and telomerase function, and is associated with diseases like dyskeratosis congenita[1][3][5]. NHP2P1, however, is functionally inert.

Other names

bA360G10.4NHP2P1