Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
NHS-like protein 1 (NHSL1)
- Target
- NHSL1
- Molecular classification
- Other (cytoskeletal regulator/protein-protein interaction scaffold; not an enzyme, receptor, transporter, ion channel, or transcription factor)[1][3][4]
01
Overview
NHS-like protein 1 (NHSL1) is a large cytoplasmic protein and member of the Nance–Horan Syndrome (NHS) protein family, which includes NHS and NHSL2. NHSL1 contains a WAVE homology domain (WHD), allowing it to physically interact with the Scar/WAVE complex—a major regulator of branched actin polymerization via the Arp2/3 complex. Functionally, NHSL1 acts as a negative regulator of cell migration by inhibiting the Scar/WAVE complex, thereby dampening Arp2/3 activity, reducing F-actin density in lamellipodia, and destabilizing lamellipodial protrusions. These actions modulate the dynamics and efficiency of cell migration, processes that are key to development and potentially disease progression, such as cancer. NHSL1 is ubiquitously expressed with tissue-specific isoforms, but it is not itself known to be a direct disease-causing protein or a drug target. NHSL1 is not considered a receptor, enzyme, transporter, or ion channel, but instead a cytoskeletal regulatory scaffold protein[1][3][4].
- Other names
- NHS-like protein 1C6orf63KIAA1357bA43P8.1NHSL1
02
Biological functions
Regulation of actin cytoskeletonNegative regulation of cell migrationControl of lamellipodia stability and dynamics[1][3][4]
03
Disease associations
Neurodevelopmental disorders (implicated through association with Nance-Horan syndrome family, but not direct causality)Other (potential—but not established—association with cancer cell migration and neuronal development)[1][4]
Beyond the preview
Go deeper on NHS-like protein 1 (NHSL1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on NHS-like protein 1 (NHSL1).