Target intelligence / Profile preview

Nicastrin (NCT)

Target: NCT
Molecular classification: Type I transmembrane protein, Scaffold protein, Receptor

Overview

Nicastrin is a crucial component of the gamma-secretase complex, a multi-subunit, membrane-embedded protease responsible for the intramembrane cleavage of various type I transmembrane proteins. This activity is central to several biological processes, including the generation of amyloid-beta (Aβ) peptides implicated in Alzheimer’s disease and the activation of Notch signaling pathways. Nicastrin acts primarily as a scaffolding protein that stabilizes the assembled gamma-secretase complex, a molecular gatekeeper, and a receptor for substrate stubs.

Mechanism of action

Gamma-secretase complex modulation; Substrate presentation disruption

Biological functions

Substrate recognitionGamma-secretase complex assemblySubstrate presentationAPP processing regulationNotch signaling regulation

Disease associations

Alzheimer's disease

Safety considerations

Off-target effects on Notch signaling

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