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Target intelligence / Profile preview
Nicotinamide Adenine Dinucleotide Metabolism Enzyme (None)
- Target
- None
- Molecular classification
- Enzyme
01
Overview
Nicotinamide adenine dinucleotide (NAD) metabolism enzymes are a group of proteins that regulate the synthesis, recycling, and consumption of NAD+, a vital coenzyme found in all living cells. These enzymes play central roles in cellular energy production, redox reactions, DNA repair, gene expression regulation, and cell signaling. Key enzymes include NAMPT, NMNAT1/2/3, NNMT, PARPs, and Sirtuins. Dysregulation is linked with aging-related decline in energy metabolism, impaired stress responses/DNA repair capacity, neurodegenerative diseases, cancer progression/metabolic disorders. Boosting or modulating activity/expression levels has therapeutic potential for age-related diseases.
02
Mechanism of action
Modulation of NAD+ metabolism (e.g., increasing NAD+ levels, inhibiting NAD+ consuming enzymes)
03
Biological functions
Redox ReactionsDNA RepairGene RegulationCellular SignalingEnergy Production
04
Disease associations
AgingNeurodegenerative diseaseMetabolic syndromeCancer
05
Safety considerations
Potential for off-target effects due to broad involvement of NAD+ in cellular processesVaried effects depending on specific enzyme and tissue context
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