Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Nicotinamide adenine dinucleotide phosphate (NADP)
- Target
- NADP
- Molecular classification
- Coenzyme, Dinucleotide, Electron carrier, Small molecule
01
Overview
Nicotinamide adenine dinucleotide phosphate (NADP) is an essential coenzyme composed of a nicotinamide ring linked to an adenine nucleotide with an additional phosphate group. It serves as a key redox carrier in anabolic metabolic reactions, most notably in photosynthesis and biosynthesis, shuttling electrons and hydrogen ions in cells. NADP exists in two interconvertible forms, the oxidized NADP+ and the reduced NADPH. Its balanced redox function is crucial for the synthesis of fatty acids and nucleic acids, cellular energy production, protection against oxidative stress, and maintenance of metabolic homeostasis across all domains of life
- Other names
- NADP(+)NADPNADPH (reduced form)Triphosphopyridine nucleotide (TPN)Codehydrase IICoenzyme II
02
Mechanism of action
N/A for direct drug targeting. Drugs acting on NADP-dependent enzymes typically inhibit or modulate the enzyme's ability to utilize NADP/NADPH for redox reactions
03
Biological functions
Electron transfer in metabolic reactionsReducing agent in anabolic pathways (lipid, nucleic acid synthesis)Oxidative stress protectionEnabling energy metabolism and ATP productionParticipates in DNA repair and detoxification
04
Disease associations
Indirectly implicated in metabolic disorders, oxidative stress conditions, and diseases where redox balance is disrupted
05
Safety considerations
None specific to NADP itself; however, disturbances in NADP/NADPH balance are associated with metabolic dysregulation and increased susceptibility to oxidative damage
06
Biomarkers
NADPH levels are sometimes measured as a biomarker for cellular redox status and oxidative stress
Beyond the preview
Go deeper on Nicotinamide adenine dinucleotide phosphate (NADP).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Nicotinamide adenine dinucleotide phosphate (NADP).