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Target intelligence / Profile preview
Nicotinamide N-methyltransferase (NNMT)
- Target
- NNMT
- Molecular classification
- Enzyme, Methyltransferase
01
Overview
Nicotinamide N-methyltransferase (NNMT) is a cytoplasmic enzyme that catalyzes the methylation of nicotinamide (NAM), using S-adenosylmethionine (SAM) as the methyl donor. This process plays a significant role in cellular metabolism, methylation balance, and disease processes, including metabolic diseases, liver disease, and cancer. NNMT's activity links the methionine cycle with NAD+ metabolism, impacting both energy homeostasis and epigenetic regulation. It is considered a therapeutic target for conditions where its overexpression or activity contributes to disease pathology.
- Other names
- None
02
Mechanism of action
Inhibition of NNMT enzymatic activity, leading to increased NAM and SAM levels and altered methylation patterns.
03
Biological functions
Energy regulationMethylation balanceNAD+ metabolismRegulation of energy expenditureRegulation of hepatic gluconeogenesisRegulation of cholesterol biosynthesisMaintenance of pluripotency
04
Disease associations
ObesityInsulin resistanceNAFLD (Non-alcoholic fatty liver disease)NASH (Non-alcoholic steatohepatitis)Cancer
05
Safety considerations
Potential disruption of NAD+ metabolismAlterations in methylation balanceOff-target effects of NNMT inhibitors
06
Interacting drugs
NNMT inhibitors
07
Biomarkers
NNMT expression levels in cancer tissuesNNMT expression in adipose tissue as a marker for obesity and insulin resistance
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