Nicotinamide nucleotide transhydrogenase antisense RNA 1 (NNT-AS1)

Nicotinamide nucleotide transhydrogenase antisense RNA 1 (NNT-AS1) is a long non-coding antisense RNA distributed mainly in the cytoplasm, transcribed from the DNA strand opposite to the NNT protein-coding gene[2][3]. It does not overlap with NNT but is co-expressed and regulates NNT expression[3]. NNT-AS1 functions predominantly as a miRNA sponge, competing for miRNA binding and thereby modulating the activity of downstream signaling pathways and affecting behaviors such as epithelial-mesenchymal transition, proliferation, invasion, migration, apoptosis, and drug resistance (notably to cisplatin) in cancer cells[2][3][5]. NNT-AS1 is dysregulated in multiple cancers, correlates with prognosis, and acts as a key regulator of ceRNA networks and cell cycle pathways[2][3][5]. Targeting NNT-AS1 may hold promise for cancer therapy, although specificity and off-target effects remain considerations[5].\n\nClarifications:\nThe query asks about "NPNT-AS1", but all relevant results reference NNT-AS1 (Nicotinamide nucleotide transhydrogenase antisense 1), not NPNT-AS1. NPNT-AS1 appears to be a misnomer or misspelled and is not recognized in biomedical literature. Therefore, the provided data is for NNT-AS1. This means "is_incorrect" should be marked true because the original name queried ("NPNT-AS1") does not correspond to a recognized target; the correct form is "NNT-AS1".[2][3][5]

Other names

Nicotinamide nucleotide transhydrogenase antisense RNA 1NNT-AS1

miRNA sponging/competing endogenous RNA activity; Regulation of sense gene NNT expression