Nicotinamide Phosphoribosyltransferase (NAMPT)

Nicotinamide phosphoribosyltransferase (NAMPT) is a key rate-limiting enzyme in the nicotinamide adenine dinucleotide (NAD+) salvage pathway. It catalyzes the condensation of nicotinamide (NAM) with 5-phosphoribosyl-1-pyrophosphate (PRPP), producing nicotinamide mononucleotide (NMN), which is then converted to NAD+. This salvage pathway is the primary source of NAD+ production in most tissues. NAMPT maintains intracellular NAD+ levels, supporting cellular energy metabolism, metabolic homeostasis, cell survival, and host defense mechanisms. Abnormal expression or activity of NAMPT has been linked to several diseases, including metabolic disorders, aging-related diseases, inflammatory conditions, and various cancers. Several small-molecule inhibitors targeting NAMPT have entered clinical trials primarily as anti-cancer agents.

Other names

NMN pyrophosphorylaseNicotinamide mononucleotide pyrophosphorylaseNicotinamide mononucleotide synthetaseNMN synthetase

Inhibition of NAMPT activity to reduce NAD+ levels.