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Target intelligence / Profile preview
Nicotinic Acetylcholine Receptor (nAChR)
- Target
- nAChR
- Molecular classification
- Ligand-gated ion channel, Receptor
01
Overview
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that respond to the neurotransmitter acetylcholine and the exogenous agonist nicotine. They are found in both the central and peripheral nervous systems, as well as at neuromuscular junctions in muscle tissue. nAChRs play a critical role in fast synaptic transmission, neuromuscular communication, and various physiological processes including cognition, movement control, and modulation of inflammatory responses.
- Other names
- Nicotinic receptorCholinergic receptor, nicotinic
02
Mechanism of action
Binding of acetylcholine or nicotine opens the channel pore, allowing Na⁺ and K⁺ influx leading to depolarization.
03
Biological functions
Fast synaptic transmissionNeuromuscular communicationModulation of inflammatory responsesCognitionMovement controlAutonomic nervous system signaling
04
Disease associations
Alzheimer's diseaseParkinson's diseaseSchizophreniaEpilepsyNicotine addictionNeurodegenerative disordersPsychiatric conditions
05
Safety considerations
Neurotoxins from snakes/spiders target nAChRsGanglionic blockade by antagonists like hexamethonium can interfere with autonomic reflexes.
06
Interacting drugs
Acetylcholine
2 more in the full profile.
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