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Nicotinic Acetylcholine Receptor (Muscle α1β1δε Subtype) (nAChR α1β1δε)
- Target
- nAChR α1β1δε
- Molecular classification
- Ligand-gated ion channel, Receptor
01
Overview
The muscle-type nicotinic acetylcholine receptor (nAChR), specifically the adult form with subunit composition α1(2)β1δε, is a ligand-gated ion channel found at neuromuscular junctions. It mediates fast synaptic transmission by responding to the neurotransmitter acetylcholine, leading to muscle contraction. Dysfunction or autoimmunity against this receptor leads to diseases such as myasthenia gravis.
- Other names
- Muscle-type Nicotinic Acetylcholine Receptor (Adult form)α1β1δε nAChRAdult Muscle nAChRAcetylcholine Receptor, Muscle subtype
02
Mechanism of action
Ligand-gated ion channel activation leading to Na+ influx and K+ efflux, resulting in membrane depolarization and muscle contraction. Blockade of the ion channel pore or non-competitive inhibition.
03
Biological functions
Synaptic transmissionNeuromuscular signalingMuscle contractionIon transport
04
Disease associations
Myasthenia GravisNeuromuscular disorders
05
Safety considerations
Sensitivity to local anestheticsAutoimmune targeting in Myasthenia Gravis
06
Interacting drugs
Acetylcholine
6 more in the full profile.
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