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Target intelligence / Profile preview
Nicotinic Acetylcholine Receptor α3α5β4 (nAChR α3α5β4)
- Target
- nAChR α3α5β4
- Molecular classification
- Ligand-gated ion channel, Receptor, Cys-loop receptor superfamily
01
Overview
The nicotinic acetylcholine receptor subtype composed of alpha 3/alpha 5/beta 4 subunits forms an essential part of fast cholinergic neurotransmission within autonomic ganglia. Its unique structure determines its biophysical properties and pharmacological sensitivities relative to other members of the family. Ongoing research targets this molecule both for understanding basic neurobiology—especially regarding addiction—and developing new therapeutic agents targeting diseases involving dysregulated cholinergic signaling.
- Other names
- α3α5β4 nAChRCHRNA3/CHRNA5/CHRNB4 receptorNeuronal nicotinic receptor α3α5β4
02
Mechanism of action
Agonist-induced opening of ion channel, leading to membrane depolarization
03
Biological functions
Fast excitatory synaptic transmissionModulation of neuronal excitabilityIon channel activityNeurotransmission
04
Disease associations
Nicotine dependenceSubstance use disordersAutonomic dysfunctionAddiction
05
Safety considerations
Potential for off-target effects due to similarity with other nAChR subtypesRisk of autonomic side effects
06
Interacting drugs
Acetylcholine
2 more in the full profile.
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