Nicotinic acetylcholine receptor α3β4 subtype (nAChR α3β4)

The Nicotinic acetylcholine receptor α3β4 subtype is a pentameric ligand-gated ion channel composed of α3 and β4 subunits[1][2][5]. It is a major subtype in autonomic ganglia and adrenal medulla, mediating fast synaptic transmission through increased permeability to sodium and potassium ions when activated. The receptor is crucial for relaying signals between central and peripheral nervous systems and is also expressed in brain regions involved in reward and addiction circuits, notably the medial habenula and interpeduncular nucleus[1][2][6]. Its physiological roles include autonomic regulation and involvement in several neurological functions, making it a validated target for therapeutic intervention, especially in addiction and neurodegenerative diseases. Selective agonists and antagonists can modulate this receptor, influencing behavioral outcomes relevant to substance use disorders and potentially cardiovascular disease. Therapies targeting this receptor face challenges due to its broad distribution and functional importance in autonomic regulation[1][6].

Other names

α3β4 nicotinic receptorganglion-type nicotinic receptorneuronal acetylcholine receptor α3β4 subtype

Agonists: Bind and activate the receptor, causing increased Na⁺ and K⁺ permeability and facilitating synaptic transmission[1][2]. Partial agonists: Partially activate the receptor leading to submaximal ion flow. Antagonists (competitive and noncompetitive): Bind to the receptor, block activation, and inhibit ion channel function, modulating downstream signaling[1][6].