Nicotinic Acetylcholine Receptor α4α6β2 (nAChR α4α6β2)

The nicotinic acetylcholine receptor (nAChR) α4α6β2 is a subtype of neuronal nAChRs, which are pentameric ligand-gated ion channels. These receptors respond to the neurotransmitter acetylcholine and the exogenous agonist nicotine. The nAChR α4α6β2 subtype is a heteromeric pentamer composed primarily of combinations of α4, α6, and β2 subunits, and is selectively expressed in dopaminergic and noradrenergic neurons. Activation induces prolonged depolarization that influences dopamine release, making it a key player in reward signaling and addiction. Its dysfunction has been implicated in addiction, Parkinson’s disease, neuropsychiatric disorders, and cognitive dysfunctions, making it a therapeutic target.

Other names

α4α6β2 nAChRα4α6β2 nicotinic receptorNicotinic receptor α4α6β2 subtype

Agonist-induced cation channel opening leading to neuronal depolarization and downstream effects on neurotransmitter release. Antagonists block agonist binding and channel activation.