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Target intelligence / Profile preview
Nicotinic Acetylcholine Receptor α6β2 Subtype (nAChR α6β2)
- Target
- nAChR α6β2
- Molecular classification
- Ligand-gated ion channel, Nicotinic acetylcholine receptor, Receptor
01
Overview
The nicotinic acetylcholine receptor (nAChR) α6β2 subtype is a heteromeric ligand-gated ion channel composed of α6 and β2 subunits. It is predominantly found in dopaminergic neurons within the mesostriatal and nigrostriatal pathways, as well as noradrenergic neurons and visual tracts. It plays essential roles in modulating dopamine release, motor control, reward mechanisms, learning, memory, and addiction-related behaviors.
- Other names
- α6β2 nAChRalpha6beta2 nicotinic receptorα6β2* nAChRs
02
Mechanism of action
Ion channel activation/inhibition leading to altered neuronal excitability and neurotransmitter release.
03
Biological functions
NeurotransmissionModulation of dopamine releaseReward processingMotor control
04
Disease associations
Parkinson's diseaseAddictionMotor control disorders
05
Safety considerations
Potential for off-target effects due to similarity with other nAChR subtypes.Desensitization of receptors with prolonged agonist exposure.
06
Interacting drugs
Acetylcholine
4 more in the full profile.
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