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Target intelligence / Profile preview
Nicotinic Acetylcholine Receptor α7 Subunit (α7 nAChR)
- Target
- α7 nAChR
- Molecular classification
- Ligand-gated ion channel, Cys-loop receptor, Receptor
01
Overview
The nicotinic acetylcholine receptor α7 subunit (α7 nAChR) is a homopentameric ligand-gated ion channel highly permeable to calcium ions. It plays critical roles in neuronal and non-neuronal tissues, mediating fast synaptic transmission and influencing various cellular processes including inflammation, cell survival, and proliferation. It is implicated in neuropsychiatric disorders, inflammatory diseases, cancer, and cardiovascular disease.
- Other names
- CHRNA7
02
Mechanism of action
Agonist or antagonist binding to the ligand-binding site, modulating ion channel opening and calcium influx.
03
Biological functions
Synaptic transmissionSynaptic plasticityNeurotransmitter releaseAction potential generationCalcium signalingInflammation modulationCell survivalCell proliferationAngiogenesisAutophagy regulation
04
Disease associations
Alzheimer's diseaseSchizophreniaCognitive disordersInflammatory diseasesStrokeMyocardial infarctionSepsisCancerCardiovascular diseaseAtherosclerosisPain modulation
05
Safety considerations
Rapid desensitizationPotential for pro- or anti-atherogenic effects depending on context/cell typeInvolvement in cancer progression
06
Interacting drugs
Acetylcholine
6 more in the full profile.
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