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Target intelligence / Profile preview
Nicotinic acetylcholine receptor (alpha7 subtype) (α7 nAChR)
- Target
- α7 nAChR
- Molecular classification
- Ligand-gated ion channel, Cys-loop receptor, Receptor
01
Overview
The α7 nicotinic acetylcholine receptor is a homopentameric ligand-gated ion channel with high calcium permeability. It is expressed in the central nervous system and peripheral tissues, playing roles in cognition, inflammation, and other processes. It is a therapeutic target for Alzheimer's disease, schizophrenia, and other conditions.
02
Mechanism of action
Upon binding agonist molecules at extracellular sites between adjacent subunits, the α7 nAChR undergoes a conformational change (“gating cycle”) that opens its central pore, allowing rapid influx of Ca²⁺ and Na⁺ ions into cells.
03
Biological functions
Synaptic transmissionLong-term memory formationLearningWorking memoryAttention regulationNeurogenesisIon channel activity
04
Disease associations
Alzheimer’s diseaseSchizophreniaCognitive dysfunctionInflammationAtherosclerosisCancer
05
Safety considerations
InflammationAtherosclerosisCancer progression
06
Interacting drugs
Acetylcholine
14 more in the full profile.
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