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Nicotinic acetylcholine receptor alpha-4 beta-2 subtype (None)

Target: None
Molecular classification: Ligand-gated ion channel, Receptor

Overview

The nicotinic acetylcholine receptor alpha-4 beta-2 subtype (α4β2 nAChR) is a neuronal ligand-gated ion channel composed of α4 and β2 subunits. It is the most abundant heteromeric nicotinic receptor in the mammalian brain and plays a central role in mediating the effects of acetylcholine and nicotine on neural activity. It is implicated in cognitive processes and growth hormone secretion. This receptor is also considered the principal biological target underlying nicotine dependence.

Other names: α4β2 nAChRalpha4beta2 nAChR

Mechanism of action

Agonist binding increases Na⁺ and K⁺ permeability across neuronal membranes, leading to post-synaptic excitation.

Biological functions

Fast synaptic transmissionNeuronal excitationModulation of growth hormone secretionCognitive processes (learning, attention)

Disease associations

Nicotine dependenceNeurodevelopmental issuesObesity

Safety considerations

Upregulation following chronic nicotine exposure contributes to addiction.Mutations can lead to neurodevelopmental issues and altered cholinergic signaling.

Interacting drugs

Acetylcholine

2 more in the full profile.

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